Uluslararası Yayınlar

Original paper
Investigation of iron’s neurotoxicity during cerebral maturation in the neonatal rat model of haemolysis
Ebru Akar, Aycan Ünalp, Gulden Diniz, Ragip Ortac, Banu Senturk, Osman Yilmaz, Muge Kiray, Merve Tepetam, Canan Coker, Sukru Cangar
Folia Neuropathol 2015; 53 (3): 262-269
DOI: https://doi.org/10.5114/fn.2015.54623

Introduction : Haemolytic disease of newborns due to rhesus and AB0 incompatibility is encountered frequently in neonatal clinics and may lead to severe haemolysis. In this study, it is suggested that important amounts of iron released with haemolysis may have a toxic effect on the brain…

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Original Article
Parental attitude, depression, anxiety in mothers, family functioning and breath-holding spells: A case control study
Kayı Eliaçık, Nurullah Bolat, Ali Kanık, Enis Sargın, Ellen Selkie, Nurhan Korkmaz, Figen Baydan, Ebru Akar, Berrak Sarıoğlu
First published: 18 April 2016
DOI: 10.1111/jpc.13094

Abstract

Aim
This study aimed to identify differences in the antenatal stressful life events, parenting style, family functioning, depression and anxiety of mothers who have children with breath-holding spells (BHS) compared with controls.

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Original Article
Atopic disease and/or atopy are risk factors for local anesthetic allergy in patients with history of hypersensitivity reactions to drugs?
Fatma Merve Tepetam, Ismet Bulut,Ebru Akar ,Emine Nur Koç,Dildar Duman, Ülkü Aka Aktürk, Dilek Ernam

Received January 13,2016; Accepted April 6, 2016; Epub June 15, 2016; Published June 30, 2016

Abstract

Background and Objective: There is some concern among physicians that a positive history of adverse reactions to drugs and/or atopic disease remains a risk factor for developing a hypersensitivity reaction to local anesthetics (LA). In the present study we aimed allergy testing to LA is justified in patients with a positive history of hypersensitivity reactions to drugs additionally by atopy and atopic diseases. Patients and Methods: A standard questionnaire regarding demographic data, history of atopic disease (asthma, allergic rhinitis, atopic dermatitis, urticaria) was filled out, total IgE and eosinophil count were assesed for each patient. Skin prick tests (SPT), intradermal test (IDT) and subcutaneus incremental challenge test (ICT) were perfomed step by step with adrenaline free aritmal (lidokain HCL 2%, Osel) and citanest (prilokain HCL 2%, Astra Zeneca).
Results: 239 patients with history of drug allergy were admitted. When we look at the results of skin tests and provocations with LA; while positive results of SPT werent found, 3 of IDT and 4 of ICT were positive. Of the all 4 patients that reacted to LA, had rhinosinusitis and a positive SPT reaction with aeroallergens, 1 had also food allergy, 2 had asthma.
Conclusion: There is no increased risk requiring performing skin and provocation test for LA in the patients with a history of hypersensitivity reaction to drugs alone but additionally by presence of atopy, atopic disease and multidrug allergy history can increase the risk of LA allergy, the amount of evidence is scarce.

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